Fibronectin fragment mediated cartilage chondrolysis. II. Reparative effects of anti-oxidants
نویسندگان
چکیده
منابع مشابه
Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokines.
Fibronectin fragments have both catabolic and anabolic activities toward articular cartilage explants in vitro. Whereas a 1 nM concentration of an N-terminal 29 kDa fibronectin fragment (Fn-f) increases the proteoglycan (PG) content of cartilage without induction of matrix metalloproteinases (MMPs), 0.1-1 microM Fn-f temporarily suppresses PG synthesis and enhances MMP release. The higher conce...
متن کاملDAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone
OBJECTIVE AND DESIGN To investigate whether endogenous damage-associated molecular patterns (DAMPs) or alarmins originated from mitochondria or nucleus stimulates inflammatory response in articular chondrocytes to cause chondrolysis which leads to cartilage degradation featured in posttraumatic osteoarthritis (PTOA). MATERIALS Primary cultures of bovine or human chondrocytes isolated from car...
متن کاملEffects of Aluminum, Silicon And Ferro Silicon Anti Oxidants in MgO C Refractories
Three different materials (aluminum, ferro -silicon and silicon) were used as antioxidants in order to prevent the decarburization process and to keep and/or increase the final properties in MgO-C refractories. Their effects were compared by measuring the physical and mechanical properties as well as oxidation and the resultant phases and microstructures, in the temperature range of 200-1600 ...
متن کاملFibronectin fragments cause release and degradation of collagen-binding molecules from equine explant cultures.
OBJECTIVE Previous experiments have shown that addition of fragmented fibronectin can induce cartilage chondrolysis. In this study we investigated the fate of the collagen- and cell-binding molecules Cartilage oligomeric matrix protein (COMP) and chondroadherin. DESIGN Equine articular cartilage explants were stimulated with the C-terminal and the N-terminal heparin-binding fragments of fibro...
متن کاملCOOH-terminal heparin-binding fibronectin fragment induces nitric oxide production in rheumatoid cartilage through CD44.
OBJECTIVES To examine the mechanism of nitric oxide (NO) production by a COOH-terminal heparin-binding fibronectin fragment (HBFN-f) in rheumatoid arthritis (RA) cartilage. METHODS Articular cartilage slices from RA knee joints and normal hip joints were cultured with HBFN-f. Secreted NO levels in conditioned media were determined. Cultures were pretreated with anti-CD44 antibody or HBFN-f-de...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 1996
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(96)00045-2